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doi:10.3390/ph18020185 Gwyer D, Wragg NM, Wilson SL

In addition, these metabolic effects do not appear to be related to their diuretic action or intended pharmacological targets, raising concerns about the long-term metabolic impact of specific diuretics, particularly in vulnerable populations, including those with metabolic syndrome

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Both datasets were fit simultaneously to the model shown, that includes NADPH binding followed by two reversible steps, the latter of which included NADP + release