Glutathione plays a vital role in protecting brain cells from oxidative stress, which is linked to cognitive decline
A sulfenic acid (RSOH) is formed, and a hydroxide anion is the leaving group
12 Current challenges in glutathione detection and biomarker analysis Quantification of GSH and related biomarkers like oxidized glutathione (GSSG) and the GSH/GSSG ratio is both clinically and research-wise challenging, predominantly due to preanalytical instability, methodological diversity, and biological interpretation difficulty
doi: 10.1177/1534735410387422 167 WenCTHusseinSZAbdullahSKarimNAMakpolSMohd YusofYA
Jacamo R, Hoang NM, Al Rawi A, Ly C, Parihar R, McQueen T, Ruvolo P, Williams P, Al-Atrash G, Konopleva M, and Andreeff M