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Garcia et al., Mol Oncol Metab, 2024) suggests that GLP-1R activation actually *downregulates* ACSL1 in TAMs to achieve a similar anti-tumor effect

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Use is experimental in many contexts, and dosing and timing are important

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Because of this, semaglutide should not be used in people with: A personal or family history of medullary thyroid carcinoma (MTC) MEN2 (Multiple Endocrine Neoplasia syndrome type 2) Other serious risks that have been reported with GLP-1 receptor agonists include pancreatitis, gallbladder disease, potential kidney problems, and (in some regulatory guidance) the need to monitor for changes in mood or suicidal thoughts