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B12 shots are administered either intramuscularly (into the muscle) or subcutaneously (just under the skin)
Injections are typically used for people whose bodies have difficulty absorbing vitamin B12 such as in certain autoimmune diseases such as Chrons disease or celiac, as well as those who have had gastric bypass surgery
When I met with the editor of the BNF a year or two again she told me that any change in the treatment would have been based on evidence based research
Dose adjustments during maintenance depend on individual response
The 50100mg daily dose range was derived from rodent models where 10mg/kg bodyweight produced measurable NNMT suppression without toxicity across 12-week administration periods
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