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On the other hand, GIP receptor internalization depends solely on arrestins and is not easily impacted by new ligands [67]

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Due to the involvement of similar population groups and drug types, we cannot conduct a subgroup analysis to reduce heterogeneity

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Future randomized studies integrating body-composition endpoints, dietary protein adequacy, resistance training, and defined postbiotic interventions will be essential to clarify the magnitude and clinical relevance of these interactions