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Thursdays readout could cast an even longer shadow of doubt over Novos obesity pipeline, particularly after the disappointing Phase II results for its small molecule oral cannabinoid receptor 1 agonist monlunabant, which in September showed modest weight reductions muddied by psychiatric side effects
The fact that weight loss improves metabolic health, which might help restore ovulation in infertile women, may also play a role
Severe, persistent upper-abdominal pain in particular is a symptom we ask patients to report, as noted in Lipase, Your Pancreas, and GLP-1 Safety
Vitamin B12 (cobalamin) is essential for red blood cell formation, nerve health, DNA synthesis, and cellular metabolism (Mayo Clinic)
Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program
