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Despite also being a tripeptide like GSH, CME inhibits tyrosinase activity through its longer side chains that tend to close the pocket entrance
One study, which also evaluated cognitive function in patients with high MMA concentrations, found no significant effects on the MDD inventory score, but only 30 of the 140 subjects had depression at baseline, which may have diluted any benefits
Large-scale trials of longer duration are needed to understand whether antioxidant supplementation might help prevent age-related cognitive decline
10.1056/NEJMoa1607141 56 MengZ.GuanZ.YuS.WuY.ZhaoY.ShenJ.et al (2025)
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