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Neuro-invasion of SARS-CoV-2 occurs via transcribrial (nose) route with damage to olfactory mucosa, and olfactory nerves, ultimately manifesting into anosmia (loss of smell) 197,198
American Journal of Health-System Pharmacy
10.14336/AD.2014.0305 Aging Dis
However, pathological modifications oxidation, glycation, citrullination, carbonylation, and enzymatic carboxyethylation of cysteine (linked to ankylosing spondylitis) can render self-proteins immunogenic, driving autoimmune disease by presenting chemically altered peptides to the immune system as foreign antigens.
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