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Metoclopramide should only be used short-term (up to 5 days) due to neurological risks, and domperidone has cardiac restrictions and is not suitable for all patients

Nothing in this article should be used to initiate, modify, discontinue, or withhold any medical treatment, including GLP-1 medications

Potential Side Effects and Digestive Changes The most common adverse effects of Wegovy involve the gastrointestinal system, with nausea, diarrhoea, vomiting, constipation, and abdominal pain reported in clinical trials, as detailed in the MHRA-approved SmPC

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This has been demonstrated in human peripheral blood mononuclear cells, where exenatide blocked NF-kB binding to DNA and downregulated both TNF and IL-1 beta expression