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Efectos adversos graves : Aunque raros, incluyen pancreatitis, enfermedad de la vescula biliar, hipoglucemia (principalmente cuando se combina con insulina o sulfonilureas) y posible exacerbacin de retinopata diabtica (particularmente con semaglutida en pacientes con retinopata preexistente y reduccin rpida de A1C)
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Likewise, Bax upregulation can be transient or reflect selective apoptosis of irreversibly damaged cells during tissue remodeling, rather than widespread apoptotic injury 53
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