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ROCK also suppresses the expression of tight junction proteins such as zona occludens-1 and occludin, impairing endothelial barrier function [37]

Aqua, Dibutyl Adipate, Propanediol, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Ethylhexyl Triazone, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, Butyloctyl Salicylate, Caprylyl Methicone, Polymethylsilsesquioxane, Diethylhexyl Butamido Triazone, Glycerin, Butylene Glycol, 1, 2-Hexanediol, Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer, Pentylene Glycol, Poly C10-30 Alkyl Acrylate, Polyglyceryl-3 Methylglucose Distearate, Behenyl Alcohol, Decyl Glucoside, Tromethamine, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Niacinamide, Centella Asiatica Leaf Water, Stearyl Alcohol, Arachidyl Alcohol, Sodium Stearoyl Glutamate, Polyacrylate Crosspolymer-6, Ethylhexylglycerin, Glutathione, Cetyl Alcohol, T-Butyl Alcohol, Dipropylene Glycol, Squalane, Benzyl Glycol, Hydrolyzed Glycosaminoglycans, Sodium Hyaluronate, Asiaticoside, Madecassic Acid, Asiatic Acid, Hippophae Rhamnoides Fruit Extract, Melaleuca Alternifolia (Tea Tree) Leaf Extract, Sodium Hyaluronate Crosspolymer, Hydrolyzed Hyaluronic Acid, Hydrolyzed Collagen, Beta-Glucan, Artemisia Annua Extract, Oryza Sativa (Rice) Extract, Nelumbo Nucifera Extract, Saccharomyces Ferment, Hydroxypropyltrimonium Hyaluronate, Solanum Melongena (Eggplant) Fruit Extract, Hyaluronic Acid, Sodium Acetylated Hyaluronate Ingredients may change

Clinical trials have demonstrated significant efficacy, with patients losing approximately 15% of body weight with semaglutide 2.4 mg (STEP 1 trial) and up to 20% with tirzepatide (SURMOUNT-1 trial) when combined with lifestyle modifications

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