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7.2 Natural polyphenols and alkaloids As an antioxidant polyphenolic compound and a free radical scavenger, resveratrol has attracted interest for the potential treatment of thyroid diseases accompanied by increased ROS production, such as autoimmune thyroiditis and hyperthyroidism ( In vitro and in vivo studies have also demonstrated that resveratrol mediates the levels of TSH and iodide uptake in thyrocytes by decreasing NIS expression ( Alkaloid antioxidant berberine was recently reported to exert positive effects in treating GD