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The number of participants in the Se-only arm varied from 16 to 105 subjects

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After a two week adjustment period the test subjects were assigned to a group receiving either a placebo treatment or 0.25 mg, 0.5 mg, or 1.0 mg of tesofensine

This transcription factor acts as a master regulator of lysosome biogenesis, thereby promoting autophagosome-lysosome clearance of A by astrocytes [69]