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However, it didnt influence endogenous glucose production, indicating that central stimulation of MC3R and MC4R receptors affected insulin sensitivity in a tissue-specific manner independently [4]

In the phase 3 REDEFINE 1 trial, the combination of cagrilintide and semaglutide yielded a mean 20% reduction in body weight over 68 weeks in adults with overweight or obesity, significantly outperforming placebo and either agent alone