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Use within 24 hours when reconstituted with plain sterile water

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The clinical trials allowed for dose adjustment based on tolerability, and your protocol should too

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[1] [5] While most GLP-1 medications are administered via subcutaneous injection (such as semaglutide, liraglutide, dulaglutide, or tirzepatide), with oral semaglutide (Rybelsus) as the only FDA-approved non-injectable option, transdermal patch delivery systems represent an emerging area of pharmaceutical development