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Ive talked about the upsides of pharmacologically boosting GLP-1 activity in terms of weight loss, given the ravages of obesity, and Ive also discussed its downsides, including common gastrointestinal reactions and muscle loss, as well as the rarer or more speculative side effects such as thyroid cancer, pancreatitis, and pancreatic cancer

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Feedback-controlled systems, where material degradation exposes new sites or alters local conditions to modulate subsequent enzyme activity, could provide a route to auto-regulated kinetics

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