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To evaluate the FOXO4 FHD-binding region in p53 TAD using a dynamic tool, we attempted to measure the hetNOE of the apo- and FHD-bound states of p53 TAD
Lipid peroxidation induces ferroptosis Lipid peroxidation is an indicator of ferroptosis, and peroxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids in cell membranes is an important step of ferroptosis [29]
* statistically significant
Discussion The vulnerability of dopaminergic neurons to minor perturbations in redox equilibrium is enhanced by the oxidative by-products of dopamine metabolism, resulting in their selective loss in Parkinsons disease
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