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Resveratrol and SRT-1720 directly activate SIRT1 or indirectly through the activation of AMP-activated protein kinase (AMPK) which is the cofactor for SIRT1 activity (Liang et al
Worked example: a representative 10 mg vial reconstituted with 2 mL of bacteriostatic water gives (10 x 1000) / 2 = 5,000 mcg/mL
Journal of Biochemical and Molecular Toxicology
Berberine has also been shown to assist weight loss by inhibiting the enzyme lipoprotein lipase, which increases fat storage (6)
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