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Secondary outcome measurements included reduction in body weight from baseline by at least 5% or 10% by week 26, changes in waist circumference, total cholesterol, HDL, LDL, VLDL, and triglycerides, and levels of different glycemic variables including HbA1C, fasting plasma glucose, fasting insulin, insulin resistance, and the functioning of beta-cells

It has been studied in laboratory, animal and limited human research involving telomerase, telomeres and melatonin-related biology

A pooled analysis of all groups shows reductions of 14.3% and 20.1% in AFM and visceral fat, respectively

Mitochondrial implication in apoptosis

The metabolic changes come from cellular-level effects rather than artificially elevated sympathetic tone