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When the pharmacological appetite suppression is reduced or withdrawn, the caloric threshold required to maintain their new weight is lower than expected, but their appetite, shaped by the neurological reward pathways that GLP-1s modulate, does not stay suppressed indefinitely without ongoing treatment

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This is why thyroid function tests at 48 weeks and ongoing monitoring are crucial

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Molecular cancer therapeutics 22(8):962-975, 2023

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