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Among these, TGF1 is recognized as the pivotal fibrogenic trigger, which transduces the fibrotic signals of multiple stimuli such as inflammatory factors, Ang-II, endothelin 1, ischemia, and high glucose 1,7,8
It is a carnitine specific transporter that disappeared during evolution: it is present in mouse, but not in chimpanzee or humans (Pochini et al., 2013)
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