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Common side effects (usually temporary): Nausea (most frequent, especially after injections) Constipation or loose stools Fatigue and low energy in the first few weeks Reduced appetite (this is also the intended effect) Injection site reactions Less common but serious: Pancreatitis (seek care immediately if you have severe abdominal pain) Gallbladder problems Changes in heart rate Rare thyroid concerns (see contraindications above) Staying well hydrated is important throughout treatment

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For the most part, the combination of the drug and the ultraviolet light (both UVA and UVB) from the sun generates toxic and inflammatory reactions that are harmful for skin cells, explains Dr

While genetics do not predict exact medication response, understanding these predispositions can support a more informed conversation with your provider about personalization needs

Since semaglutide does not cause addiction or intoxication, it is not included in employer drug screening programs