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GLP-1 Receptor Agonists and Noncardiometabolic Outcomes

Luteal Phase : After ovulation, progesterone rises to prepare the uterus for potential pregnancy

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Clin Nephrol 2003;59(1):24-30

TS inhibition by 5FU regulates mitochondrial biogenesis through mTORPGC1 signalling 5FU has a multimodal mechanism of action: promoting DNA damage directly via its metabolite FdUTP or by inhibition of TS via FdUMP, depleting the pool of thymidine available for DNA synthesis, and causing RNA damage via FUTP (Fig