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Sermorelin binds to GHRH receptors in the pituitary gland, prompting it to release endogenous growth hormone in a pattern closer to the body's natural rhythm

Early-phase clinical trial data, including results from a Phase 2 trial published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023), demonstrated substantial weight reduction in participants receiving retatrutide with some individuals losing more than 20% of their body weight over 48 weeks

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To illustrate this trend, data released by the World Health Organization, an international entity headquartered in Switzerland, indicated in March 2024 that in the year 2022, one out of every eight individuals worldwide experienced obesity