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Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus: a randomised controlled trial (LEAD-5 met+SU)
PMID: 29 DixonS
IR metformin is typically taken twice daily with meals, while ER versions are designed to be taken once daily and may be easier on the stomach
Most evidence supports its use as an adjunct ingredient in multi-agent formulations rather than a primary treatment
Esophageal injury from Ozempic, Wegovy, and other injectables is a rare but serious complication
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