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A Nature Scientific Reports 2016 study showed GHK-Cu had no cytotoxicity to human keratinocytes at concentrations up to 5,800 M over 72 hours and did NOT induce inflammatory biomarkers (IL-1, IL-8, HSPA1A, FOSL1) unlike other copper compounds, concluding GHK-Cu has a low potential of inducing skin irritation

Department of Oral Biology, Goldschleger School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel * Correspondence: Rachel Amir ([email protected]) Received date: 2024-03-26 Accepted date: 2024-10-08 Online published: 2024-10-24 Supported by This work was supported by the Israel Science Foundation (ISF Grant no

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Levels naturally decline with age, leaving cells more exposed to environmental and metabolic stress