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Biochim Biophys Acta 876 , 309317 (1986)
The trial enrolled 445 adults with obesity and moderate-to-severe knee osteoarthritis pain (without diabetes), randomized 1:1:1 to 9mg, 12mg, or placebo over 68 weeks
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It also says a provider should confirm stable thyroid hormone levels, rule out thyroid cancer history, and establish a baseline TSH before semaglutide is started at all
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