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Before applying to live cells, the cytotoxicity of TPE-DCV is evaluated by using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay (Figure S13)
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The internal Km value is in the millimolar range, i.e., in the average intracellular carnitine concentrations (Pochini et al., 2004)
Immune cells are likely affected by G6PD-d in two major ways
The evaluation belongs to the provider, who weighs whether the change offers real benefit against the disruption of transitioning
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