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Over-expression of miR-17-92 in HUVECs can protect ECs from erastin-induced ferroptosis by targeting the zinc lipoprotein (A20)-acyl-CoA synthetase long-chain family member 4 (ACSL4) axis that could protect glutathione peroxidase 4 (GPX4) and inhibit ROS production (Xiao et al., 2019)
[1] [8] This mechanism underlies strict warnings that MB should not be administered alongside selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), certain tricyclic antidepressants, or other MAO inhibitors, except in life-threatening situations
Stanley WC, Recchia FA, Lopaschuk GD
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Investigated for its role in satiety-related signaling pathways and glucose-associated biomarkers in controlled research models
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