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Effects on osteoblasts and bone formation MOTS-c promotes osteoblast proliferation, differentiation, and mineralization through the TGF-beta/Smad signaling pathway
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Potential side effects include local irritation of the nasal passages
Gene expression analysis showed upregulation of survival pathways (Egr1, Akt1, Kras, Src, Foxo, Srf, VEGFR2, NOS1, NOS3) and downregulation of inflammatory mediators (NOS2, NFB)
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