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The Scripps Research LoCITT-T trial is investigating exactly this question

When coupled with regular exercise, particularly a mix of aerobic and strength training, this effect is magnified: Enhanced Calorie Deficit: The appetite suppression from GLP-1s makes it easier to adhere to a reduced-calorie diet, while exercise further increases calorie expenditure, creating a more robust deficit for weight loss

Earlier studies using these mice include (5-7, 101)

Approval (2017) Semaglutide Treatment of Excessive Body Weight in Obese PCOS Patients Unresponsive to Lifestyle Programs (September 12, 2023) ttps: The Role of Lifestyle Interventions in PCOS Management: A Systematic Review (Jan 16, 2025) Markers of insulin resistance in Polycystic ovary syndrome women: An update (March 15, 2022) Ranking the dietary interventions by their effectiveness in the management of polycystic ovary syndrome: a systematic review and network meta-analysis (Feb 22, 2024) Implementing the international evidence-based guideline of assessment and management of polycystic ovary syndrome (PCOS): how to achieve weight loss in overweight and obese women with PCOS

They can advise on the safest timing and may suggest a gradual dose reduction or a brief pause of 12 weeks maximum, followed by a structured restart protocol