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Food and Drug Administration, Center for Drug Evaluation and Research (CDER)
This response is metabolic, not pharmaceutical
The progression moves through 7.5 mg, then 10 mg , then 12.5 mg, and potentially up to 15 mg
Guideline Recommendations Figure 3 includes the 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America HF guidelines and the 2023 European Society of Cardiology guidelines for the diagnosis and treatment of acute and chronic heart failure
however, sacubitril/valsartan is recommended for its comprehensive cardiovascular effects
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