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While the results from studies using native OXM in rodents and humans were promising, the short half-life in vivo and the large amount of peptide required to produce an effect made it a poor choice as a treatment in humans
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Theyre generally more potent than GLP-1 agonists due to their mechanism of action
The blood levels of CRP and TNF- cytokines were increased in rats given whole-body gamma irradiation
What exists is mechanistic plausibility, clinical observation, and the accumulated experience of practitioners working at that edge
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