Unlike semaglutide (Ozempic/Wegovy), which only activates the GLP-1 pathway, tirzepatide simultaneously engages both GIP and GLP-1 receptors , producing significantly superior weight loss results
Peters AL, Buschur EO, Buse JB, et al
However, these modifications to the molecule could not solve the problem of degradation and poor absorption when taken by mouth
Encadr : Le saviez-vous
As previously described (Strbe et al., 2021), intestinal tissue damage was analyzed using a histologic scoring scale adapted from Chui and coworkers (Chui et al., 1970) on a scale of 05 (normal to severe) in three categories (mucosal injury, inflammation, and hyperemia/hemorrhage) for a total score of 015, as described by Lane and coworkers (Lane et al., 1997)