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Practical factorssuch as insurance coverage, approved indication (type 2 diabetes vs obesity), drug availability, previous side effects, and co-existing health conditionsusually matter more than subtle mechanistic differences when deciding which medication to use and how aggressively to dose it

Although the history of CETP inhibitor CV outcome trials has been uninspiring, it is important to recognize that issues with prior trials included significant off-target adverse effects

They express interest in future developments that might lead to formulations or adjunct therapies that minimize gastrointestinal side effects while maintaining the drugs efficacy

Adverse effects of phentermine are dose-dependent and include increased blood pressure, dizziness, headache, tremor, and dry mouth

Peptides retain 95-100% potency