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Thus, although 5-HT cannot cross the BBB directly, platelet-derived 5-HT is able to increase the level of CNS 5-HT, which might link the intestinal 5-HT with brain function [131]

Wallace, K

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Ive had patients cut their migraine days in half just by making small changes they didnt think would matter. Noting the intricate connections between the gut, brain, and metabolism, Parnacott added that treating migraine is not just about a single drug