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GLP-1 Q.GLP-1 A. PMDA

Abbreviations GLP1RAs: Glucagon-like peptide 1 receptor agonists PCOS: Polycystic ovary syndrome RCT: Randomized controlled trial WMD: Weighted mean difference SMD: Standardized mean difference RR: Risks ratio CI: Confidence interval SD: Standard deviations IR: Insulin resistance GI: Gastrointestinal GnRH: Gonadotropin-releasing hormone LIRA: Liraglutuide EXE: Exenatide MET: Metformin CC: Clomifene citrate NM: Not mentioned BID: Twice a day QD: Once a day COMBI: Combined group MF: Menstrual frequency PR: Pregnancy rate IVF: In vitro fertilization TBF: Total body fat BMI: Body mass index WC: Waist circumference HOMA-IR: Homeostasis model assessment-insulin resistance TT: Total testosterone fT: Free testosterone FAI: Free androgen index DHEAS: Dehydroepiandrosterone sulphate SHBG: Sex hormone binding globulin OGTT: Oral glucose tolerance test BP: Blood pressure ART: Assisted reproductive technology GDM: Gestational diabetes mellitus FDA: Food and Drug Administration EMA: European Medicines Agency HPO axis: Hypothalamus pituitary ovary axis CRP: C-reactive protein IL-18: Interleukin 18 TNF-: Tumor necrosis factor IL-6: Interleukin 6 References Yildiz BO, Bozdag G, Yapici Z, Esinler I, Yarali H

Her NAION risk remains very low

Key takeaways To ensure proper absorption and prevent skin issues like lipohypertrophy, its important to rotate insulin injection sites regularly, keeping about an inch between each site

Melatonin is a hormone associated with sleep regulation