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A study published in the New England Journal of Medicine found that participants lost an average of 20.9% of their body weight over 72 weeks when taking the highest dose
This result contrasts a recent study that found no evidence of differences in macrovascular disease prevention for GLP-1RAs compared with metformin in individuals with type 2 diabetes (whose hepatic steatosis status was unclear) [39]
5.2.6 Who its best for / Ideal Candidates Although Metformin is not FDA-approved for obesity or weight loss , it is widely used off-label in clinical practice, especially for: Individuals looking for a low risk, cheap, option to support weight maintenance post-GLP1 use Individuals with insulin resistance Women with PCOS-related weight issues 6
PlexusDx compounded semaglutide injections start at just $189/mo (or $149/mo on the 6-month plan), making long-term therapy affordable as you navigate this critical maintenance phase where consistency prevents weight rebound
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