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Conclusion: In congestive hepatopathy, mechano-stress in the liver sinusoids activates YAP/TAZ and enhances CTGF expression in LSECs, which may contribute to the development of liver fibrosis and portal hypertension
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The compound binds HGF with sub-nanomolar affinity (Kd 65 pM) and is investigated as a synaptogenic research molecule with notable properties unusual for a peptide: oral bioavailability and blood-brain barrier permeability
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