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Finally, we note that severe oxidative stress causes a "methyl trap" such that the model concentration of 5mTHF more than doubles
This promotes optimal cellular performance and helps protect against cellular damage
as shown in experimental studies using cerebellar granular cell cultures exposed to glutamate after being treated with riboflavin or pyridoxine (82, 83)
This suppresses transcription of pro-inflammatory genes, reducing TNF-alpha production and IL-6 secretion
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