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216 In an observational study, at 3 months, 36% of 101 participants responded (50% seizure reduction) to diet therapy, and 16% were seizure-free

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8 Compared with placebo, once weekly tirzepatide significantly reduced the combined risk of cardiovascular death or worsening HF events (hospitalisation or an urgent hospital visit requiring intravenous therapy)

We then selected the top 2.5% (empirically by the effect size of differences between microbial profiles, Fig