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More precisely, among them, the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 , induced by p53 in response to OS and involved in the regulation of cell cycle arrest, replication, cellular proliferation, and apoptosis, competes with KEAP1 for the binding to NRF2 through the DLG motif, thus preventing NRF2 ubiquitination, and increasing its stabilization [184, 185]

Furthermore, a correlation was observed between homocysteine and B12 levels and hyperactivity

"Cobalamin Deficiency: Clinical Picture and Radiological Findings"

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Both are known for their antioxidant properties and are commonly included in skincare and wellness routines