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GH axis stimulation in pre-clinical ageing models: Studies examining GHRH analogue + GHRP combinations in aged rodent models documented restoration of GH pulse amplitude and IGF-1 levels toward younger values with findings establishing that somatotroph GH secretory capacity is largely preserved in aged animals despite reduced hypothalamic GHRH drive, and that pharmacological dual-pathway somatotroph stimulation can overcome age-associated GH decline
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Its peptide structure and receptor selectivity support consistent experimental outcomes across controlled, non-clinical in-vitro systems
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