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Therefore, polypharmacology can be used in the search for more effective and less toxic treatments
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Rare side effects may include mild headache or fatigue, which typically resolve quickly under doctor supervision
For example, in mouse macrophages stimulated with LPS, mTOR enhances the translation of inflammatory genes mediated by TLR4, acting through the eIF4EBP1/ribosomal protein S6 kinase like 1 (RPS6KL1)/MAF bZIP transcription factor (MAF, also known as c-MAF) pathway
While generally considered safe for most individuals, the evidence supporting their use specifically for GLP-1-related digestive symptoms remains limited and largely anecdotal
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