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Schrepf A, Bradley CS, O'Donnell M et al: Toll-like receptor 4 and comorbid pain in interstitial cystitis/bladder pain syndrome: A multidisciplinary approach to the study of chronic pelvic pain research network study

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The time of Maria Panagioti and Natasha Tyler was funded by the National Institute for Health and Care Research (NIHR) Greater Manchester Patient Safety Translational Research Centre (award number: PSTRC-2016-003)

Uncertainty also is present when the available studies appear to demonstrate efficacy, but the total number of patients exposed to a particular treatment is small (e.g., cimetidine studies)