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GLP-1 therapy isn't appropriate during pregnancy or breastfeeding, or for anyone with a personal or family history of medullary thyroid carcinoma or MEN2, a history of pancreatitis, or certain other conditions
The placebo effect and natural adaptation to tirzepatide over time make it difficult to attribute changes specifically to the B6 component
Whilst neither substance typically causes kidney damage in healthy individuals, both require adequate renal function for safe use
Warnings and Cautions Do not exceed the stated recommended daily dose
(2026) Impact of semaglutide on fat mass, lean mass and muscle function in patients with obesity: the SEMALEAN study
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