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The immune system is already compromised
Limitations and strengths The strength of our study entails the relatively large number of participants who practically cover all socio-economic groups within the examined community, thus enhancing generalizability of the findings of this study
254 Moreover, H3K18la in astrocytes contributes to bilirubin encephalopathy by upregulating nucleotide-binding oligomerization domain 2 (NOD2) expression, which boosts downstream MAPK and NF-B signaling pathway activation, exacerbating astrocytic neuroinflammation and pyroptosis
Cystic fibrosis is characterized by Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction in the airway epithelium, leading to impaired mucociliary clearance and defective innate immune responses which promote chronic bacterial colonization