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Tirzepatide second target: GIP receptors GIP (glucose-dependent insulinotropic polypeptide) is an incretin hormone released from the gut after eating
PMID 4980931
TRIUMPH-4, the first completed Phase 3 trial, showed 28.7% average body weight loss at 68 weeks on retatrutide 12mg versus 2.1% on placebo, as reported by Eli Lilly in December 2025 (peer-reviewed publication pending)
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