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16 additional subjects were added to account for dropouts

While a qualified physician may also assess central nervous system structural abnormalities or neurological problems, usually central nervous system damage is determined through psychological, speech-language, and occupational therapy assessments to ascertain clinically significant impairments in three or more of the Ten Brain Domains

The mTOR-independent cascade, canonically designated as the Beclin1/B-cell lymphoma 2 (Bcl-2)/c-Jun N-terminal kinase 1 (JNK1) signaling axis, operates through coordinated regulation by autophagy-related genes (ATG) ( EA ameliorates CIRI through mTOR pathway upregulation, modulating autophagy activity (Wang M

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