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The implications ripple across pipeline strategy, market-access planning and therapeutic positioning
Some cut corners
Transporta metales pesados, por ejemplo, Hg, fuera de las clulas y el cerebro
Studies have examined the dose-response relationships for MC1R-mediated melanogenesis with MT-II , comparing potency with MT-1 and native -MSH to establish the structure-activity contribution of cyclisation to MC1R agonist potency , and have characterised the kinetics of tyrosinase upregulation, melanosome distribution, and melanin transfer to keratinocytes downstream of MT-II-induced MC1R activation
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